
Zuo Y, Lin A, Chang P, Gan WB (2005) Development of long-term dendritic spine stability in diverse regions of cerebral cortex. Grutzendler J, Kasthuri N, Gan WB (2002) Long-term dendritic spine stability in the adult cortex. The increase in dendritic outgrowths is rapid - within 24 -48 hours of giving estrogen, there is a measurably dramatic change in the number of connections between brain cells. The cells Steinman discovered, which he dubbed dendritic cells, are born in the bone marrow but appear all over the body - in skin, kidneys, liver, gut and elsewhere.

#DEFINE DENDRITE PROFESSIONAL#
As dendritic cells were relatively rare, itt took until the 1980’s for them t become accepted as professional APCs.From The American Heritage® Dictionary of the English Language, 5th Edition. Compared with dendritic cells, macorphages were present in much greater numbers, were evenly spread throughout the body and had were known to present antigens. Before this, immunologists generally thought that macrophages were the main APC in the immune system. He found these cells in the spleen and it was later discovered that the cells were present in all lymphoid and most non-lymphoid tissues. During development, they develop branched projections called “dendrites”, which is why the cells are so named.ĭendritic cells were first described by Ralph Steinman in the 1970’s. Once activated, dendritic cells move to the lymph tissue to interact with to interact with T cells and B cells and help shape the adaptive immune response. Immature forms are also found in the blood.
#DEFINE DENDRITE SKIN#
This is to provide a long lasting source of antigen that the B cells can take up themselves and present to T cells.ĭendritic cells are found in tissue that has contact with the outside environment such as the over the skin (present as Langerhans cells) and in the linings of the nose, lungs, stomach and intestines.

After an initial antibody response has occurred due to an invading body, dendritic cells found in the germinal centre of lymph nodes seem to contribute to B cell memory by forming numerous antibody-antigen complexes. Dendritic producing cytokines and other factors that promote B cell activation and differentiation.
